Table 5.
Factors associated with respiratory virus co-infection in children with MP pneumonia
| Variables | OR | P value | aOR* | P value | aOR** | P value |
|---|---|---|---|---|---|---|
| Age at diagnosis of pneumonia, years | 0.881 (0.800–0.970) | 0.010 | 0.879 (0.798–0.969) | 0.009 | 0.898 (0.809–0.997) | 0.045 |
| †Duration of fever during illness ≥ 6 days | 2.105 (1.074–4.123) | 0.030 | 2.394 (1.172–4.892) | 0.017 | 3.329 (1.540–7.196) | 0.002 |
| Total duration of hospitalization, days | 1.083 (1.005–1.167) | 0.037 | 1.070 (0.992–1.154) | 0.080 | 1.060 (0.979–1.147) | 0.152 |
| Severity of pneumonia based on chest radiography findings at admission | ||||||
| Mild | Ref. | Ref. | Ref. | |||
| Moderate | 2.050 (0.609-6.900) | 0.246 | 2.746 (0.787–9.578) | 0.113 | 2.485 (0.589–10.490) | 0.215 |
| Severe | 3.094 (0.820-11.672) | 0.096 | 4.602 (1.154–18.353) | 0.031 | 4.184 (0.875–20.011) | 0.073 |
| WBC, x 103/µL | 1.085 (1.008–1.168) | 0.030 | 1.065 (0.988–1.148) | 0.102 | 1.053 (0.974–1.139) | 0.193 |
| AST ≥ 44 IU/L† | 3.300 (1.577–6.906) | 0.002 | 3.491 (1.616–7.543) | 0.001 | 5.202 (2.211–12.238) | < 0.001 |
| ALT ≥ 33 IU/L† | 2.749 (1.290–5.856) | 0.009 | 3.325 (1.478–7.477) | 0.004 | 4.756 (1.903–11.887) | 0.001 |
| LDH ≥ 805.3 IU/L† | 6.250 (2.878–13.574) | < 0.001 | 5.704 (2.602–12.504) | < 0.001 | 6.555 (2.772–15.503) | < 0.001 |
| CRP, mg/dL | 0.939 (0.866–1.019) | 0.132 | 0.972 (0.898–1.051) | 0.471 | 0.960 (0.885–1.042) | 0.333 |
| MP-specific IgM titer at the time of admission, index | 1.129 (1.014–1.257) | 0.026 | 1.109 (0.993–1.239) | 0.065 | 1.121 (0.995–1.263) | 0.061 |
| Response to treatment | ||||||
| Good response | Ref. | Ref. | Ref. | |||
| Slow response | 2.187 (1.041–4.599) | 0.039 | 2.187 (1.041–4.599) | 0.039 | 2.197 (0.931–5.185) | 0.072 |
| No/poor response | 4.354 (1.374–13.800) | 0.012 | 4.354 (1.374–13.800) | 0.012 | 4.410 (1.273–15.277) | 0.019 |
Bold values denote statistical significance
aOR adjusted odds ratio, AST aspartate aminotransferase, ALT alanine aminotransferase, CRP C-reactive protein, IgM immunoglobulin M, LDH lactate dehydrogenase, MP Mycoplasma pneumoniae, NA not applicable, PCR polymerase chain reaction, Ref. reference
*Adjusted by age and sex
**Adjusted by age, sex, and bacterial coinfection identified using Pneumobacter PCR or respiratory culture from sputum samples
†The variables were dichotomized based on the mean values