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. 2022 May 14;28(18):1934–1945. doi: 10.3748/wjg.v28.i18.1934

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Histone deacetylases classification. Histone deacetylases (HDAC) can be divided into two major classes, namely Zn-dependent and NAD dependent. Class I (HDAC 1–3 and 8), Class IIa (HDAC 4, 5, 7 and 9), Class IIb (HDAC 6 and 10) and Class IV (HDAC 11) are Zn-dependent HDAC. Class III (SIRT1 to 7) is NAD⁺ dependent HDAC. HDAC: Histone deacetylases. The figure in this review paper is created by using BioRender.com by the authors.