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. 2022 May 26;10(5):e003960. doi: 10.1136/jitc-2021-003960

Figure 6.

Figure 6

PC7A initiates CXCL9 expression through STING pathway. (A) Quantification of IFNβ expression in tumor derived CD45+ cells and CD45- cells 24 hours after I.T. treatment of PBS (NC), PC7A, antigen peptide or vaccine (n=3). (B) Quantification of CXCL9 expression in tumor derived CD45+ cells and CD45- cells 24 hours after PC7A, antigen peptide or vaccine I.T. treatment (n=3). (C) Quantification of IFNβ expression in WT and STING-/- mice 24 hours after I.T. treatment (n=4). (D) Quantification of CXCL9 mRNA expression in WT and STING-/- mice 24 hours after PC7A, antigen peptide or vaccine I.T. treatment (n=4). (E) Schematic of STING dependent PC7A induced CXCL9 expression. *P<0.05. One-way ANOVA t-test. ANOVA, analysis of variance; I.T., intratumoral; NS, not significant.