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. 2022 May 13;7(5):1237–1247. doi: 10.1021/acssensors.2c00333

Figure 1.

Figure 1

Pictures showing different approaches for BBB-oC configuration. (A) PMMA layers in stack conformation with TEER system included. Reproduced with permission from (19). Copyright 2021 Elsevier. (B) Flank configuration consisting of two layers of PDMS using a collagen gel to mimic the natural extracellular matrix in brain. Reproduced with permission from ref (20). Copyright 2016 The Authors under Creative Commons Attribution 4.0 International License, published by Springer Nature. (C) PDMS layers in flank position and hydrogel consisting in collagen, matrigel and hyaluronic acid and its TEER system. Reproduced with permission from ref (22). Copyright 2017 Elsevier. (D) Polycaprolactone/poly(d,l-lactide-co-glycolide) (PCL/PLGA) microfluidic tubular configuration was made by freeze-coating a 3D-printed sacrificial template. Reproduced with permission from ref (24). Copyright 2020 Elsevier. (E) Tubular structure microchannel via viscous finger patterning technique using type I collagen hydrogel and its TEER system included, Reproduced with permission from ref (25). Copyright 2020 Wiley. (F) PDMS devices used to perform a vasculogenesis model. Reprinted with permission from ref (27). Copyright 2017 The Authors under Creative Commons Attribution 4.0 International License, published by Springer Nature.