Table 1. Proposed Analytes and Biosensors for BBB-oC Monitoring.

detection focus	analytes/biomarkers	recommended bipreceptor	recommended biosensor
drugs	Paclitaxel, Simvastatine, Fluvastatin, ...	aptamer	Aptabeacon
cytotoxicity	LDH and/or glutamate	lactate oxidase and glutamate oxidase	enzymatic sensor
ions	Ca+2, Na+, K+, and/or Fe2+/3+	ionophores	ISE
neuro-inflammation markers	cytokines, chemokines, CAMS, MMPs	aptamer and/or antibody	aptabeacon and/or impedance immunosensor
ROS	hydrogen peroxide	HRP	enzymatic sensor