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CSF cfDNA documents molecular characterization of EGFR-mutated NSCLC with LM. A Frequency of shared versus CSF-private or plasma-private alterations in paired CSF-plasma samples. B Discordance of on-target and off-target resistant mechanisms to osimertinib upon LM progression between paired CSF and plasma. CSF, cerebrospinal fluid; amp, amplification; mut, mutation
