Table 1:

Effects of AR activation and inhibition on the angiogenic process of wound healing

Receptor activation/ inhibition	Effect on angiogenesis and wound healing	Reference
β2-AR activation	inhibition of mobilization, proliferation, and tube formation capabilities of dermal EC; delayed wound healing	62
β2-AR activation	inhibition of secretion of fibroblast growth factor 2 from human dermal microvascular endothelial cells (HDMEC), and VEGF from keratinocytes; delayed wound healing	62
β–AR inhibition	stimulates MMP‐2 and MMP‐9 and promotes collagen turnover and less vascularized and more organized collagenous granulation tissue; faster wound healing	59
α1/α2 AR deletion	increases angiogenesis, TGF‐β 1/2/3 expression, keratinocyte migration, collagen deposition, and myofibroblastic differentiation; faster wound healing	68