Table 2.

Blood pressure, biochemical tests of urine and blood and histology result in db/m and db/db mice

	2K db/m	1K db/m	2K db/db	1K db/db Vehicle	1K db/db Losartan
Systolic blood pressure (mmHg)	134±6	130±8	118±13#	125±9	90±12††
Heart rate (bpm)	648±61	656±37	572±53	582±53	575±59
UACR	107±67	34±7*	594±247#	3104±986*	829±500†
Ccr BM (ml/min/kg)	20.9±4.6	16.9±4.2	43.8±22.2	20.6±7.6	27.7±17.1
BUN (mg/dl)	20.4±1.7	29.1±4.3**	24.3±4.3	46.6±19.8	32.6±1.8
Sirius red positive area (%)	0.82±0.62	1.88±1.75	3.63±2.45	6.54±8.24	5.15±1.08

Systolic blood pressure and heart rate were measured at 36 weeks of age. Biochemical tests of urine and blood were measured at 40 weeks of age. The Sirius red positive area assessed the fibrous area of the kidney at 42 weeks of age. Each value is represented as mean ± standard deviation (n=3–6).

^#p<0.05; significantly different from db/m group.

^*p<0.05,

^**p<0.01; significantly different from 2K group.

^†p<0.05,

^††p<0.01; significantly different from Vehicle group.

UACR, urinary albumin-creatinine ratio; Ccr BM, creatinine clearance body mass corrected; BUN, blood urea nitrogen.