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Histologic Features of Histiocytic Disorders
| LCH | ECD/JXG | RDD | |
|---|---|---|---|
| HLA-DR | ++ | − | + |
| CD1a | ++ | − | − |
| CD14 | +/− | ++ | ++ |
| CD68 | +/− | ++ | ++ |
| CD163 | − | + | ++ |
| CD 207 (Langerin) | +++ | − | − |
| Factor XIIIa | − | ++ | − |
| Fascin | − | ++ | + |
| Birbeck granules | + | − | − |
| Hemophagocytosis | +/− | − | − |
| Emperiopolesis | − | − | + |
LCH, Langerhans cell histiocytosis; ECD, Erdheim Chester disease; JXG, juvenile xanthogranuloma; HLH, hemophagocytic lymphohistiocytosis; RDD, Rosai-Dorfman disease; LC, epidermal Langerhans cell
Adapted from 22
