Table.

Heterogeneity and Directional Pleiotropy

Ancestry	Exposure	N SNPs	Q Statistic	I 2	P Value	P for Intercept	Statistical Power
European
	T2D unadjusted for BMI	165	507.2	67.7%	<0.001	0.531	0.93
	T2D adjusted for BMI	115	416.3	72.6%	<0.001	0.932	0.88
	Fasting glucose	58	113.5	49.8%	<0.001	0.297	0.80
	HbA1c	60	416.3	51.9%	<0.001	0.901	0.59
East Asian
	T2D unadjusted for BMI	129	144.2	11.2%	0.156	0.532	0.85
	T2D adjusted for BMI	91	111.0	18.9%	0.066	0.790	0.69
	Fasting glucose	11	5.7	0.0%	0.838	0.987	0.24
	HbA1c	15	12.3	0.0%	0.584	0.708	0.35

T2D, type 2 diabetes.