Table 4.
Clinical trials of herbal medicines registered in (A) clinical trials registry in India (CTRI) and clinicaltrials.gov.
| Clinical trials registered in CTRI | ||||||||
|---|---|---|---|---|---|---|---|---|
| Clinical trial Id | Agent | Phase | Estimated starting date | Period | Patients | Age group | Dose | |
| CTRI/2020/05/025156 | AYUSH-64 | 3/4 | May 18, 2020 | 1 year | 60 | 18–60 year | 2 Tablets (500 mg each) T.I.D. after meal for 1 month | |
| CTRI/2020/05/025338 | AYUSH-64 | 2/3 | June 02, 2020 | 3 month 5 days | 40 | 18–60 year | 2 capsules (500 mg each) T.I.D. Orally for 14 days | |
| CTRI/2020/05/025341 | Kiratiktadi Kwath and Ashwagandha Churna with Yoga | N/A | June 02, 2020 | 3 months | 30 | <20 or >60 years | Gugguludhoopan B.I.D. in COVID-19 wards. AYUSH Kadha O.D. in the early morning. Kirtikatdi kwath: 30 ml B.I.D. Ashwagandha churna 5 gm O.D. with lukewarm water. Yoga sessions twice a day. |
|
| CTRI/2020/05/025171 | Samshamani Vati, Anutaila, rock salt, and turmeric | 2 | May 16, 2020 | 3 months | 5000 | 19–60 years | SamshamaniVati 250 mg B.I.D. after food with water. Application of Anutaila 2 drops in each nostril O.D. after bath. Gargle with warm water mixed with rock salt and turmeric. Yoga and Pranayama- for 8 weeks. |
|
| CTRI/2020/05/025425 | Chyawapanprash | 3/4 | June 02, 2020 | 2 month 15 days | 50 | 20–60 years | 12 gm Avaleha B.I.D. orally Onan empty stomach at least 1 h before breakfast and 2 h after dinner at night. Anupana: Warm water. Duration of therapy: 30 days. |
|
| CTRI/2020/05/025429 | Ashwagandha | 2/3 | June 10, 2020 | 3 months | 5000 | 18–68 years | Ashwagandha capsule with standard prophylactic care. | |
| CTRI/2020/05/025370 | Guduchi Ghan Vati | N/A | June 04, 2020 | 1 month 15 days | 40 | 18–60 years | 500 mg B.I.D. orally for 30 days. | |
| CTRI/2020/05/025093 | Yashtimadhu tablet | 2/3 | May 18, 2020 | 1 month 15 days | 1200 | 18–68 years | Yashtimadhu tablet −250 mg 2 tablets B.I.D. for 1 month. | |
| CTRI/2020/05/025166 | Ashwagandha tablet | 2/3 | May 19, 2020 | 6 months | 1200 | 18–68 years | Ashwagandha tablet (250 mg) two tablets twice daily for one month | |
| CTRI/2020/05/025088 | Guduchi tablet | ½ | May 20, 2020 | 6 months | 1200 | 18–68 years | Guduchi 500 mg B.I.D. for one month. | |
| CTRI/2020/05/025205 | Arsenicum album 30C | 2/3 | May 24, 2020 | 2 months | 33000 | 1–90 years | Arsenicum album 30C will be given to the high danger COVID-19 patients and those located in the containment zone, 4 pills of medicine will be given orally B.I.D. for 7 days. | |
| CTRI/2020/04/024882 | Kashaya (Decoction) | 3 | April 28, 2020 | 1 year | 60 | >18 years | 90–100 ml of Kashaya of Guduchi stem added with 2 gm of powdered dried long pepper B.I.D. | |
| CTRI/2020/05/025332 | Ashwagandha tablet | 2 | May 28, 2020 | 3 months | 400 | 20–69 years | 250 mg, 2 tablets B.I.D. for 12 weeks. | |
| Clinical trials registered in clinicaltrials.gov | ||||||||
| Trial Id | Status | Period | Study type | Participant | Age group | Description | ||
| NCT04716647 | Completed | Interventional | 28 | 20–70 years | In this trial, the therapeutic efficacy of ashwagandha and Guduchi was evaluated | |||
| NCT04480398 | Completed | Jun 2020–July 2020 | Interventional | 91 | 18–75 Year | Guduchi Ghan Vati was tested in asymptomatic COVID 19 patients. | ||
| NCT04920773 | Completed | May 2020–June 2020 | Interventional | 216 | 18–60 years | Guduchi Ghan Vati was tested as prophylaxis for COVID-19. | ||
| NCT04395976 | Not yet recruiting | Jun 2020–Oct 2020 | Interventional | 120 | 18 years and older (Adult, Older Adult) | The study is aimed to prevent people from COVID-19 and those who must met confirmed, COVID-19 patients. The treatment is based on the combination therapy by herbs, nutritional advice, food items, lifestyle, yoga along with standard approvals and it relies on symptoms and personality. | ||
| NCT04351542 | Completed | Mar 2020–Apr 2020 | Interventional | 32 | 18–60 years | The study is based on the Ayurveda-based assessment; self-managed approaches were recommended. | ||
| NCT04345549 | Completed | Feb 2020–Mar 2020 | Interventional | 18 | 18–60 years | In this, participants are advised to self-isolate for seven days and maintain self-care according to directions. The participants were advised to Constitution-based Ayurveda treatment using herbs, lifestyle, and yoga. Participants were suggested to use Ginger/lemon/turmeric/honey recommended as per individual. | ||
| NCT04387643 | Completed | Mar 2020–Apr 2020 | Observational | 52 | 18–60 years | Ayurvedic Kadha was suggested in this study. | ||