Table 2.
Rates of resistance to ceftriaxone, cefotaxime and cefazidime in Shigella flexneri and S. sonnei isolated from Europe-America and Asia-Africa during 1998–2012
| District | Study period | S. flexneri | S. sonnei | ||
|---|---|---|---|---|---|
| R% (95% CI) | Weight % | R% (95% CI) | Weight % | ||
| Ceftriaxone | |||||
| Europe-America | 1998–2000 | 0·3 (0·0–1·7) | 12·8 | 0·1 (0·0–0·4) | 9·7 |
| 2001–2003 | 1·1 (0·2–2·6) | 23·3 | 0·1 (0·0–0·3) | 33·5 | |
| 2004–2006 | 0·6 (0·1–1·4) | 42·9 | 0·4 (0·2–0·7) | 34·4 | |
| 2007–2009 | 0·4 (0·0–1·6) | 21·0 | 0·3 (0·1–0·7) | 22·4 | |
| 2010–2012 | NR | NR | NR | NR | |
| Overall | 0·6 (0·3–1·1) | 100·0 | 0·2 (0·1–0·4) | 100·0 | |
| Asia-Africa | 1998–2000 | 0·4 (0·1–0·8) | 22·3 | 1·3 (0·6–2·2) | 25·7 |
| 2001–2003 | 1·4 (0·7–2·4) | 33·4 | 2·0 (0·9–3·5) | 39·5 | |
| 2004–2006 | 2·8 (1·4–4·8) | 25·7 | 6·2 (2·4–11·5) | 24·2 | |
| 2007–2009 | 10·6 (3·3–21·4) | 14·8 | 15·6 (8·1–25·1) | 9·4 | |
| 2010–2012 | 32·1 (1·1–79·5) | 3·8 | 6·7 (1·0–16·9) | 1·1 | |
| Overall | 3·0 (2·0–4·2) | 100·0 | 3·5 (2·3–5·0) | 100·0 | |
| Cefotaxime | |||||
| Europe-America | 1998–2000 | NR | NR | NR | NR |
| 2001–2003 | NR | NR | NR | NR | |
| 2004–2006 | 0·6 (0·1–3·2) | 100·0 | 0·2 (0·1–1·6) | 100·0 | |
| 2007–2009 | NR | NR | NR | NR | |
| 2010–2012 | NR | NR | NR | NR | |
| Overall | 0·6 (0·1–3·2) | 100·0 | 0·2 (0·1–1·6) | 100·0 | |
| Asia-Africa | 1998–2000 | 4·3 (0·6–11·4) | 24·5 | 0·6 (0·1–1·8) | 30·8 |
| 2001–2003 | 2·4 (0·8–4·9) | 29·3 | 0·8 (0·3–1·6) | 33·9 | |
| 2004–2006 | 4·0 (1·2–8·4) | 27·9 | 4·8 (0·3–14·6) | 22·5 | |
| 2007–2009 | 21·6 (8·1–39·2) | 11·8 | 13·5 (4·4–26·5) | 7·0 | |
| 2010–2012 | 34·0 (25·5–43·1) | 6·5 | 14·2 (1·7–36·0) | 5·8 | |
| Overall | 6·3 (3·7–9·7) | 100·0 | 2·8 (1·3–4·8) | 100·0 | |
| Ceftazidime | |||||
| Europe-America | 1998–2000 | NR | NR | NR | NR |
| 2001–2003 | 0·7 (0·1–4·2) | 46·8 | 0·3 (0·1–2·1) | 84·0 | |
| 2004–2006 | 0·7 (0·6–5·7) | 26·6 | 2·1 (1·9–17·3) | 8·0 | |
| 2007–2009 | 0·7 (0·6–5·7) | 26·6 | 2·1 (1·9–17·3) | 8·0 | |
| 2010–2012 | NR | NR | NR | NR | |
| Overall | 0·7 (0·0–2·7) | 100·0 | 0·5 (0·0–2·3) | 100·0 | |
| Asia-Africa | 1998–2000 | 1·9 (0·1–9·0) | 11·7 | 0·6 (0·1–3·6) | 10·0 |
| 2001–2003 | 2·8 (0·3–14·3) | 34·3 | 1·3 (0·0–5·7) | 39·0 | |
| 2004–2006 | 10·4 (0·1–34·3) | 29·6 | 9·5 (1·3–24·0) | 33·5 | |
| 2007–2009 | 16·6 (0·9–46·1) | 19·5 | 17·5 (2·8–73·6) | 11·9 | |
| 2010–2012 | 11·6 (2·8–25·3) | 4·9 | 0·7 (0·6–5·8) | 5·6 | |
| Overall | 7·0 (1·9–14·8) | 100·0 | 4·4 (1·4–9·0) | 100·0 | |
R, Resistance; CI, confidence interval; NR, no result.
Weight % refers to how much each row contributes to the ‘Overall’ row.