Table 4.

Association between herpes simplex and subsequent malignancy: estimated age-adjusted hazard ratios according to age group, site and gender

Age (no. of events in men + women)	Site	Men HR (95% CI)	Women HR (95% CI)
All (70 + 88)	All	0·91 (0·49–1·70)	1·06 (0·64–1·74)
⩽50 (5 + 32)	All	0·80 (0·08–8·08)	1·17 (0·52–2·63)
51–65 (30 + 28)	All	1·01 (0·41–2·46)	0·85 (0·33–2·18)
>65 (35 + 28)	All	0·68 (0·35–2·11)	1·18 (0·49–2·87)
>65 (11 + 0)	Lung	0·84 (0·18–3·97)	†
>65 (9 + 0)	Prostate	‡	†
>65 (0 + 8)	Breast	†	1·18 (0·24–5·82)
>65 (1 + 7)	Colorectal	†	1·42 (0·24–8·54)
>65 (6 + 7)	Haematological	2·06 (0·37–11·56)	1·48 (0·29–7·44)

HR, Hazard ratio; CI, confidence interval.

^†No cases of malignancy were recorded in at least one of the comparison groups.

^‡Only one case of malignancy was recorded in at least one of the comparison groups.