Table 4.
Clinical analysis of 40 patients who had isolates with and without the three genetic characteristics [tcdA/tcdB, binary toxin (cdtA/cdtB) genes and tcdC deletion]
| Characteristic | Patients with isolates with tcdA/tcdB, cdtA/cdtB genes and tcdC deletion | P value | |
|---|---|---|---|
| No (n = 34) | Yes (n = 6) | ||
| Male sex | 16 (47·1%) | 2 (33·3%) | 0·53 |
| Any underlying disease | 26 (76·5%) | 5 (83·3%) | 0·71 |
| Death | 3 (8·8%) | 2 (33·3%) | 0·09 |
| Any antibiotic therapy | 22 (64·7%) | 2 (33·3%) | 0·20 |
| Operation | 8 (26. 7%) | 0 (0%) | 0·71 |
| Steroid use | 16 (47·1%) | 2(33·3%) | 0·30 |
| Anti-ulcer drugs | |||
| Proton pump inhibitor | 14 (41·2%) | 2 (33·3%) | 0·45 |
| H2 blocker | 3 (8·8%) | 0 (0%) | 1·00 |
| Symptoms | |||
| Fever | 14 (41·2%) | 2 (33·3%) | 0·54 |
| Abdominal discomfort | 5 (14·7%) | 1 (16. 7%) | 0·59 |
| Invasive diseases (bacteraemia) | 7 (20·6%) | 3 (50%) | 1·00 |
| Laboratory findings | |||
| White blood cell (cell/μl) | 6543 ± 4929·9 | 11073·3 ± 8324·1 | 0·07 |
| Haemoglobin (g/dl) | 9·81 ± 1·63 | 10·68 ± 1·64 | 0·24 |
| Neutrophil (%) | 62·89 ± 26·78 | 62·27 ± 47·86 | 0·97 |
| Platelet (cell/μl) | 145313 ± 99145 | 190667 ± 125371 | 0·33 |
| BUN (mg/dl) | 21·66 ± 13·97 | 54·18 ± 38·92 | 0·10 |
| Creatinine (mg/dl) | 1·09 ± 0·93 | 2·57 ± 2·76 | 0·25 |
| Sodium (mequiv/l) | 137·4 ± 3·98 | 132·3 ± 4·73 | 0·049 |
| Potassium (mequiv/l) | 3·78 ± 0·55 | 3·57 ± 0·40 | 0·53 |
| CRP (mg/dl) | 2·70 ± 2·54 | 12·00 ± 14·66 | 0·39 |
| Albumin (mg/dl) | 3·45 ± 0·67 | 3·2 ± 0·62 | 0·56 |
| Bilirubin-total (mg/dl) | 1·60 ± 2·37 | 0·78 ± 0·24 | 0·13 |
| AST (IU/l) | 37·93 ± 31·66 | 15·33 ± 3·79 | 0·002 |
| ALT (IU/l) | 48·30± 49·66 | 10·50 ± 0·71 | 0·001 |
| Mortality | 3 (8·8%) | 2 (33·3%) | 0·09 |
| tcdA/tcdB, cdtA/cdtB genes and tcdC deletion | |||
ALT, Alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CRP, C-reactive protein.
Values given are mean ± standard deviation or n (%).
Bold values indicate significant difference (P < 0·05).