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Systemic inflammatory response syndrome in AP. IL‐6 transsignaling involves the interaction between IL‐6 and a soluble IL‐6 receptor which increases gp130‐dependent STAT3 activation. Nuclear translocation of STAT3 results in release of cytokines such as CXCL1 which leads to acute lung injury. Cytokine secretion in macrophages depend on nuclear translocation of RelA
