FIGURE 5.

Colocalization theory. Under physiologic conditions, digestive zymogens and lysosomes do not interact with each other within pancreatic acinar cells. During AP an apical block results in redistribution of lysosomes, which then colocalize with digestive zymogens. Colocalization allows the lysosomal enzyme cathepsin‐B to activate the digestive zymogens within the pancreatic acinar cell, resulting in cell damage. Basolateral release of granules might occur leading to damage to the interstitial space