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. 2022 May 12;36(3):847–864. doi: 10.1111/jvim.16437

FIGURE 6.

FIGURE 6

Endoplasmic reticulum stress and the unfolded protein response. Under physiologic conditions endoplasmic reticulum stress is countered by the unfolded protein response, which prevents cellular injury. However, in AP excessive and prolonged ER stress results in a maladaptive UPR and subsequent upregulation of NF‐κB, resulting in acinar cell injury