FIGURE 7.

Pancreatic enzyme leakage and the role of fatty acids in the pathogenesis of AP. Leakage of pancreatic enzymes, particularly classical pancreatic lipase, into the intrapancreatic and peri‐pancreatic fat results in the generation of nonesterified fatty acids. These nonesterified fatty acids lead to systemic inflammation and organ failure; thus, the level of visceral adipose tissue might influence the clinical course of AP Source: This figure was adapted with permission from de Oliveira et al. J Clin Invest. 2020;130(4):1931‐1947