Table 2.

Results of exposure to trimethoprim

	No. of exposed	No. of miscarriages	HR (95% CI)	HR (adjusted 95%CI)
Exposure in the trimester before conception
Trimethoprim and combinations (J01EA01 and J01EE01)	812	73	1·15 (0·91–1·44)	0·88 (0·70–1·11)
Sulfamethizole and trimethoprim (J01EE01)	108	10	1·19 (0·64–2·20)	0·83 (0·45–1·55)
Trimethoprim (J01EA01)	704	63	1·14 (0·89–1·46)	0·89 (0·69–1·13)
Exposure in the trimester after conception
Trimethoprim and combinations (J01EA01 and J01EE01)	265	31	2·09 (1·46–2·99)	2·04 (1·43–2·91)
Sulfamethizole and trimethoprim (J01EE01)	34	3	1·43 (0·46–4·43)	1·28 (0·41–3·97)
Trimethoprim (J01EA01)	233	28	2·12 (1·50–3·19)	2·27 (1·56–3·31)
Sulfamethizole (J01EB02)	23 286	1587	0·95 (0·90–1·00)	0·97 (0·92–1·02)

HR, Hazard ratio; CI, confidence interval.