Figure 1. Fate mapping demonstrates an increased contribution of adult hematopoiesis-derived cells to CD68⁺ macrophages in the choroid plexus and perivascular space in APP/PS1 mice.

Representative images demonstrating GFP expression in CD68⁺ cells in WT^{mTmG;Flt3-Cre} and APP/PS1^{mTmG;Flt3-Cre} mice, between 10 and 17 months of age, in the (A) choroid plexus, (C) perivascular space, and (E) meninges, (B, D, and F) with quantitation of GFP expression in this cell population in the respective populations. Scale bar: 20 μm (A, C, and E). n = 7–8/group. *P < 0.05, t test.