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. 2022 Jun 1;132(11):e156243. doi: 10.1172/JCI156243

Figure 1. Study design and workflow.

Figure 1

HPAP, working with Network for Pancreatic Organ Donors with Diabetes (nPOD), identifies organ donors of interest (recent-onset T1D, antibody+ donors, and control participants). For organ donors younger than 30 years of age without diabetes, the organ procurement organization (OPO), using HPAP/nPOD protocols and reagents, screens for the presence of AAbs (GADA, IA-2, mIAA, ZnT8). If a suitable organ donor is identified, pancreatic and immune tissues are shipped to Penn for processing. The tissue and islets are then analyzed for hormone secretion, multiplex imaging, molecular phenotyping, transcriptomics, and immunofluorescence staining at Vanderbilt and UPenn. All data are coregistered and integrated into a publicly accessible database (PANC-DB; https://hpap.pmacs.upenn.edu).