Figure 4. Uhrf1 depletion induces upregulation of RA-related genes in synovial fibroblasts.

(A) Volcano plot showing log₂ fold change (log₂FC) and statistical significance (P value) of differences between Uhrf1^ΔCol6a1 and Uhrf1^fl/fl SFs. (B) KEGG pathway analysis and (C) GO analysis among upregulated genes using DAVID Bioinformatics Resources. Significantly enriched terms are illustrated by gene counts and P values. (D) Venn diagram comparing upregulated genes (log₂FC > 1, P < 0.05) following Uhrf1 depletion in SFs, chondrocytes, and hematopoietic stem cells (HSCs) by RNA-Seq analysis of data from this study and data in GEO GSE92641 and GSE85450). Data in A were obtained from 3 independent experiments.