Fig. 1.

Phylogenetic tree of the HPV16 variants based on E6E7 and LCR sequences. A. Phylogenetic tree based on 98 E6E7 sequences. B. Phylogenetic tree based on 84 LCR sequences. The Neighbor-Joining method and the Tamura 3-Parameter model were used to construct the phylogenetic tree by MEGA version 7.0. The standard sequences included NC_001526.4, K02718 (A1), AF536179 (A2), HQ644236 (A3), AF534061 (A4), AF536180 (B1), AF472509 (C1) and AF402678 (D3). Numbers closest to the branch points are bootstrap values (1,000 replicates). Both E6E7 and LCR sequences of 41 samples were marked in red. . (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)