Table 7.

Nucleotide mutations of HPV-16 LCR and the predicted binding sites for transcription factors.

Sublineage	Nucleotide mutation site	Transcription factors
A1	A7166G	△FOXA1
A1	T7170G	△FOXA1
A1	A7172C	△FOXA1
A1	C7308T, C7312T	NFIL3
A1	C7312T	△ETS1
A1	A7496C	△VAX1
A1	C7597T	SOX9
A1	A7727C	△PHOX2A
A1	C0013T	RAX
A4	G7218C	STAT3, HOXC11
A4	T7363G	△VAX1
A4	A7659G	△ETS1
A4	G7825A	△SOX9, FOS

Note: △ mutation site resulted in loss the transcription factor.