Table 3.

Net benefit of risk-stratified screening for the reference case, accounting for the harms of the screening test across different scenarios.

NWS	NWD-1		Marker does not discriminate between incidence and mortality				Marker discriminates between incidence and mortality
		Screen All	Screen 50%	Screen 33%	Screen 10%	Highest net benefit for less predictive marker	Screen 50%	Screen 33%		Screen 10%
750	30	7.33	6.27	5.37	2.73	5.40	7.77	7.73	5.92
750	20	6.67	5.73	4.92	2.51	4.93	7.23	7.26	5.65
750	10	4.67	4.13	3.58	1.85	3.53	5.63	5.86	4.83
500	30	6.67	5.93	5.15	2.66	5.07	7.43	7.51	5.85
500	20	6.00	5.40	4.70	2.44	4.60	6.90	7.04	5.58
500	10	4.00	3.80	3.36	1.78	3.20	5.30	5.64	4.76
250	30	4.67	4.93	4.49	2.46	4.07	6.43	6.85	5.65
250	20	4.00	4.40	4.04	2.24	3.60	5.90	6.38	5.38
250	10	2.00	2.80	2.70	1.58	2.20	4.30	4.98	4.56
100	20	−2.00	1.40	2.06	1.64	0.70	2.90	4.40	4.78
50	20	−12.00	−3.60	−1.24	0.64	−0.40	−2.10	1.10	3.78
25	20	−32.00	−13.60	−7.84	−1.36	−2.40	−12.10	−5.50	1.78
1500	30	8.00	6.60	5.59	2.79	5.73	8.10	7.95	5.99
2500	50	8.80	7.16	6.03	3.00	6.24	8.66	8.41	6.23

Bold values denote the strategy with the highest net benefit.