Table 4.

Net benefit of risk-stratified screening for common cancer screening approaches for a marker that does not distinguish between incidence and mortality.

Screening approach	NWS	NWD-1		Marker AUC = 0.75				Marker AUC = 0.65
				Marker that does not discriminate between mortality and incidence			Highest net benefit for marker that discriminates between mortality and incidence	Marker that does not discriminate between mortality and incidence			Highest net benefit for marker that discriminates between mortality and incidence
			Screen all	Screen 50%	Screen 33%	Screen 10%		Screen 50%	Screen 33%	Screen 10%
PSA	500	10	4.00	3.80	3.36	1.78	4.20	3.20	2.34	1.00	3.60
Pap Smear	1500	30	0.67	0.73	0.67	0.37	1.40	0.60	0.45	0.20	1.27
Mammography	500	20	4.85	4.48	3.93	2.06	4.50	3.80	2.77	1.17	3.81
Mammography (alternative I)	350	15	3.94	4.01	3.61	1.96	4.03	3.33	2.46	1.07	3.35
Mammography (alternative II)	500	10	4.70	4.36	3.83	2.01	4.39	3.69	2.69	1.14	3.72
Lung CT	350	15	−1.19	−0.10	0.17	0.26	0.44	-	-	-	-

Bold values denote the strategy with the highest net benefit.