Table 2.
Carriage rates of Streptococcus pneumoniae (SPn) and Staphylococcus aureus (SA) serotypes in relation to the number of received doses of heptavalent pneumococcal conjugate vaccine (PCV7) and to age in 620 children aged between 0 and 4 years attending day-care centres
| (Co-)carriage rate, n (%)† | Age <15 months | |||||||
|---|---|---|---|---|---|---|---|---|
| Unvaccinated | 1 or 2 PCV7 doses | 3 PCV7 doses | 4 PCV7 doses | P value‡ | Age <15 months | Age 15–48 months (all unvaccinated) | P value§ | |
| (n = 26) | (n = 14) | (n = 87) | (n = 42) | (n = 169) | (n = 457) | |||
| SA | 3 (11·5) | 7 (50·0) | 26 (30·2) | 10 (24·4) | 46 (27·5) | 77 (17·0) | ** | |
| SPn (all types) | 9 (34·6) | 3 (21·4) | 30 (34·9) | 19 (46·3) | 61 (36·5) | 170 (37·5) | ||
| SPn vaccine types | 5 (20·0) | 1 (7·1) | 9 (10·7) | 3 (7·7) | 18 (11·1) | 77 (17·6) | * | |
| SPn non-vaccine types | 3 (12·0) | 2 (14·3) | 19 (22·6) | 14 (35·9) | ** | 38 (23·5) | 78 (17·8) | |
| SPn vaccine type 6B | 1 (4·0) | 0 | 3 (3·6) | 1 (2·6) | 5 (3·1) | 24 (5·5) | ||
| SPn vaccine type 14 | 0 | 0 | 2 (2·4) | 1 (2·6) | 3 (1·9) | 16 (3·7) | ||
| SPn vaccine type 19F | 1 (4·0) | 0 | 2 (2·4) | 0 | 3 (1·9) | 15 (3·4) | ||
| SPn vaccine type 23F | 1 (4·0) | 1 (7·1) | 2 (2·4) | 1 (2·6) | 5 (3·1) | 17 (3·7) | ||
| SPn non-vaccine type 6A | 2 (8·0) | 1 (7·1) | 2 (2·4) | 2 (5·1) | 7 (4·2) | 22 (5·0) | ||
| SPn non-vaccine type 19A | 0 | 0 | 2 (2·4) | 1 (2·6) | 3 (1·9) | 13 (3·0) | ||
| SA and SPn | 1 (3·8) | 0 | 7 (8·1) | 4 (9·8) | 12 (7·2) | 18 (4·0) | ||
| SA and SPn vaccine types | 0 | 0 | 1 (1·2) | 0 | 1 (0·6) | 11 (2·5) | ||
| SA and SPn non-vaccine types | 0 | 0 | 6 (7·1) | 4 (10·3) | # | 10 (6·2) | 7 (1·6) | ** |
†
Denominator excludes the 20 isolates that were not typed.
‡
χ2 test for linear trend in the association between number of PCV7 doses and carriage rate.
§
χ2 test of the association between carriage rate and age group.
#
P ⩽ 0·10, * P ⩽ 0·05, ** p ⩽ 0·01.