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. 2022 May 17;9:848491. doi: 10.3389/fmed.2022.848491

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Copyright © 2022 Wang, Liu, Jia, Wang, Lu, Tian, Yang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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N-AC alleviated renal dysfunction and pathological changes at 6 h after ROSC. (A) The dynamic changes of serum creatinine (Scr) level after ROSC. (B) The dynamic changes of serum blood urea nitrogen (BUN) level after ROSC. (C) The dynamic changes of serum neutrophil gelatinase- associated lipocalin (NGAL) level after ROSC. (D) The renal pathological damage was evaluated by HE stains (400 × magnification). (E) Quantitative dates of TIS. SHAM, sham group; CONT, control group; N-AC, N-AC group. Sham group, n = 5; Control group, n = 7; N-AC group, n = 7. Data are expressed as mean ± SD. * P < 0.01, vs. sham group; # P < 0.01, vs. control group. SHAM, Sham group; CONT, Control group; N-AC, N-AC group.