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. 2022 May 17;13:872470. doi: 10.3389/fimmu.2022.872470

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Copyright © 2022 Lawal, Wu and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NL0C-015A exhibited anti-non-small-cell lung cancer (NSCLC) activities via modulation of Hippo, EGFR-MEK, and NF-κB-TOR pathways in NSCLC. (A) Heatmap of the top 100 upregulated and downregulated genes. (B) Plot of the effect of NLOC-015A treatment on expression of Hippo, EGFR-MEK, and NF-κB-TOR pathways. (C) GSEA plot of NLOC-015-mediated processes. (D) Cell viability plot showing that treatment with XMU-MP-1 attenuated the antiproliferative properties of NLO0C-015A in both H1975 and H1299 cells. *p < 0.05, **p < 0.01, ***p < 0.001.