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Exosomes induce differential expression of miRNA in hFOB. (A) Changes in miRNA expression in hFOB are detected. High-throughput sequencing is performed, and analysis of miRNA-seq data is conducted in both groups. (B) The target genes of differentially expressed miRNAs are predicted by Gene Ontology (GO) analyses. (C) KEGG analysis of target genes is performed. miRNA is enriched in many typical osteogenic pathways, including TGF-β, MAPK, PI-3K and Wnt pathway.
