Table 1.
Description of studies included in the meta-analysis
| Year | Sensitivity | Specificity | Type of antibody | Stage of the disease | Type of antigen | Reference |
|---|---|---|---|---|---|---|
| 1980 | 0·948 | 0·995 | IgM | Unspecified | Crude extract | [15] |
| 1988 | 0·820 | 0·772 | IgM | Unspecified | Crude extract | [16] |
| 1992 | 1·000 | 1·000 | IgM | Unspecified | Crude extract | [17] |
| 0·500 | 1·000 | IgA | Unspecified | Crude extract | ||
| 1995 | 0·921 | 0·975 | IgM | Unspecified | Crude extract | [18] |
| 1996 | 0·899 | 0·974 | IgM | Unspecified | Crude extract | [19] |
| 1997 | 0·959 | 0·462 | IgM + IgG | Unspecified | Crude extract | [20] |
| 0·984 | 0·979 | IgM | Acute | Crude extract | [21] | |
| 1997 | 0·698 | 1·000 | IgG | Acute | Crude extract | |
| 0·762 | 0·979 | IgA | Acute | Crude extract | ||
| 1998 | 0·991 | 0·988 | IgM | Unspecified | Crude extract | [22] |
| 1999 | 0·360 | 0·968 | IgM | Acute | Crude extract | [23] |
| 0·760 | 0·968 | IgM | Convalescent | Crude extract | ||
| 0·522 | 0·952 | IgM | Acute | Crude extract | [8] | |
| 1999 | 0·893 | 0·977 | IgM | Acute | Crude extract | |
| 0·969 | 0·939 | IgM | Convalescent | Crude extract | ||
| 2000 | 0·548 | 0·969 | IgM | Unspecified | Crude extract | [24] |
| 0·837 | 0·938 | IgM + IgG | Unspecified | Crude extract | ||
| 2001 | 0·965 | 0·986 | IgM | Unspecified | Crude extract | [25] |
| 0·930 | 0·824 | IgM | Unspecified | Crude extract | ||
| 2001 | 0·560 | 0·911 | IgG | Acute | Sepecific antigen | [26] |
| 0·940 | 0·911 | IgG | Convalescent | Sepecific antigen | ||
| 2001 | 0·596 | 0·958 | IgM | Acute | Crude extract | [5] |
| 0·895 | 0·992 | IgM | Convalescent | Crude extract | ||
| 2001 | 0·570 | 0·958 | IgM | Acute | Crude extract | [27] |
| 0·844 | 0·989 | IgM | Convalescent | Crude extract | ||
| 2002 | 0·519 | 0·951 | IgM | Unspecified | Crude extract | [28] |
| 0·500 | 0·902 | IgM | Unspecified | Crude extract | ||
| 0·346 | 0·978 | IgM | Unspecified | Crude extract | ||
| 0·423 | 0·978 | IgM | Unspecified | Crude extract | ||
| 2002 | 0·975 | 0·988 | IgM | Unspecified | Crude extract | [29] |
| 2002 | 0·896 | 0·927 | IgG | Unspecified | Crude extract | [30] |
| 0·875 | 0·964 | IgM | Unspecified | Crude extract | ||
| 2003 | 0·486 | 0·969 | IgM | Acute | Crude extract | [31] |
| 0·750 | 0·969 | IgM | Convalescent | Crude extract | ||
| 2003 | 0·500 | 0·787 | IgM | Acute | Crude extract | [2] |
| 0·877 | 0·872 | IgM | Convalescent | Crude extract | ||
| 2004 | 0·835 | 0·802 | IgM | Unspecified | Crude extract | [9] |
| 0·541 | 0·634 | IgG | Unspecified | Crude extract | ||
| 0·976 | 0·965 | IgM | Unspecified | Crude extract | ||
| 0·788 | 0·713 | IgG | Unspecified | Crude extract | ||
| 0·965 | 0·941 | IgM | Unspecified | Crude extract | ||
| 0·847 | 0·792 | IgG | Unspecified | Crude extract | ||
| 2004 | 1·000 | 0·962 | IgM | Unspecified | Crude extract | [32] |
| 2005 | 0·875 | 0·976 | IgM | Acute | Crude extract | [33] |
| 0·990 | 0·939 | IgM | Acute | Crude extract | ||
| 2006 | 0·936 | 0·933 | IgM | Unspecified | Crude extract | [7] |
| 2006 | 0·883 | 0·891 | IgM | Unspecified | Crude extract | [34] |
| 2006 | 0·609 | 0·656 | IgM | Acute | Crude extract | [35] |
| 0·652 | 0·454 | IgM | Convalescent | Crude extract | ||
| 2007 | 0·792 | 0·950 | IgM | Acute | Crude extract | [36] |
| 0·875 | 0·875 | IgM | Acute | Crude extract | ||
| 0·960 | 0·950 | IgM | Convalescent | Crude extract | ||
| 0·920 | 0·875 | IgM | Convalescent | Crude extract | ||
| 0·755 | 0·977 | IgM | Acute | Crude extract | ||
| 2007 | 0·681 | 0·963 | IgG | Acute | Crude extract | [37] |
| 0·932 | 0·993 | IgG | Convalescent | Crude extract | ||
| 0·788 | 1·000 | IgG | Convalescent | Crude extract | ||
| 2008 | 1·000 | 0·977 | IgM | Convalescent | Crude extract | [36] |
| 2008 | 0·696 | 0·968 | IgM | Acute | Sepecific antigen | [38] |
| 0·667 | 0·968 | IgM | Convalescent | Sepecific antigen | ||
| 0·630 | 1·000 | IgG | Acute | Sepecific antigen | ||
| 0·861 | 1·000 | IgG | Convalescent | Sepecific antigen | ||
| 2008 | 0·898 | 0·981 | IgM | Unspecified | Crude extract | [39] |
| 2008 | 0·963 | 0·911 | IgM | Unspecified | Sepecific antigen | [40] |
| 2009 | 0·856 | 0·993 | IgM | Acute | Sepecific antigen | [41] |
| 1·000 | 0·993 | IgM | Convalescent | Sepecific antigen | ||
| 0·833 | 0·993 | IgM | Acute | Sepecific antigen | ||
| 0·922 | 0·993 | IgM | Convalescent | Sepecific antigen | ||
| 2009 | 0·850 | 0·933 | IgM | Unspecified | Crude extract | [42] |
| 2010 | 0·434 | 0·882 | IgM | Unspecified | Sepecific antigen | [3] |
| 0·943 | 1·000 | IgG | Unspecified | Sepecific antigen | ||
| 2011 | 0·777 | 0·820 | IgG | Unspecified | Crude extract | [43] |
| 0·777 | 0·680 | IgG | Unspecified | Sepecific antigen | ||
| 0·690 | 0·831 | IgG | Unspecified | Sepecific antigen | ||
| 0·642 | 0·895 | IgG | Unspecified | Sepecific antigen | ||
| 0·624 | 0·930 | IgG | Acute | Crude extract | ||
| 0·624 | 0·775 | IgG | Acute | Sepecific antigen | ||
| 0·661 | 0·873 | IgG | Acute | Sepecific antigen | ||
| 0·514 | 0·944 | IgG | Acute | Sepecific antigen | ||
| 0·956 | 0·977 | IgG | Convalescent | Crude extract | ||
| 0·824 | 0·724 | IgG | Convalescent | Sepecific antigen | ||
| 0·758 | 0·782 | IgG | Convalescent | Sepecific antigen | ||
| 0·725 | 0·872 | IgG | Convalescent | Sepecific antigen | ||
| 0·828 | 1·000 | IgG | Convalescent | Crude extract | ||
| 0·793 | 0·864 | IgG | Convalescent | Sepecific antigen | ||
| 0·724 | 0·773 | IgG | Convalescent | Sepecific antigen | ||
| 0·862 | 0·773 | IgG | Convalescent | Sepecific antigen |