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. 2022 May 17;14:806200. doi: 10.3389/fnagi.2022.806200

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Copyright © 2022 Ma, Liu, Zhang, Xiang, Zhang and Chu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Cluster tree drawn using the weighted gene co-expression network analysis method. Each branch represents a gene; y-axis represents the cluster distance. (B) Cluster dendrogram with soft threshold and 7 merged modules: 668 genes in blue module, 60 genes in green-yellow module, 7,130 genes in gray module, 153 genes in magenta module, 550 genes in pink module, 1,116 genes in turquoise module, and 323 genes in yellow module. (C) Module-trait relationships, where blue module has the highest correlation with diseases (cor = 0.73, p = 1e^–16). (D) Scale independence; x-axis represents the value of power and y-axis represents R. (E) Mean connectivity; x-axis represents the value of power and y-axis represents the average connected number of all nodes. (F) Correlation between genes in blue module and corresponding traits (cor = 0.47, p = 5.2e^–38).