Fig. 4.

Monocyte and CD4⁺ T cell clusters at baseline and post-infliximab: relationships with changes in CRP and anhedonia. At baseline, the number of CD16⁺ monocytes negatively correlated with CD4⁺ T_naive cells (r_s = 1.0, p < 0.001)(A). Change in the number of CD14⁺ monocytes (B) and CD4⁺ T_EM-like cells (C) predicted change in anhedonia scores as measured by SHAPS-C (r_s = 1.0, p < 0.001 each). Infliximab-induced decrease in hsCRP was also associated with change in the number of both CD14⁺ monocytes and CD4⁺ T_EM-like cells (r_s = 1.0, p < 0.001 each)(D). hsCRP, high sensitivity C-reactive protein; EM, effector memory; SHAPS-C, Clinician-rated Snaith-Hamilton Pleasure Scale.