Table 5.
Univariable regression analysis and multivariable regression analysis for PFS of metastatic sites.
| Characteristics | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Age (years) | 0.953 (0.918,0.989) | 0.011 | 0.970 (0.938,1.004) | 0.082 |
| ALT (U/L) | 1.006 (0.995,1.018) | 0.273 | ||
| AST (U/L) | 0.999 (0.988,1.010) | 0.851 | ||
| Leukocyte | 0.979 (0.771,1.243) | 0.860 | ||
| Neutrophils | 0.948 (0.659,1.362) | 0.772 | ||
| Lymphocytes | 0.715 (0.336,1.521) | 0.383 | ||
| Erythrocyte (◊1012/L) | 1.010 (0.436,2.337) | 0.982 | ||
| Platelet | 1.003 (0.996,1.010) | 0.409 | ||
| Primary tumor size (cm) | 1.126 (0.936,1.354) | 0.207 | ||
| Metastatic tumor size (cm) | 1.151 (0.863,1.534) | 0.338 | ||
| Number of iodine 125 seeds | 1.023 (1.002,1.044) | 0.035 | 1.042 (1.014,1.071) | 0.004 |
| Gender | ||||
| Male | Ref | |||
| Female | 0.646 (0.236,1.772) | 0.396 | ||
| HBV | ||||
| Yes | Ref | |||
| No | 1.431 (0.645,3.176) | 0.378 | ||
| Cirrhosis | ||||
| Yes | Ref | |||
| No | 0.772 (0.299,1.994) | 0.593 | ||
| Primary tumor number | ||||
| 1 | Ref | |||
| ≥2 | 1.980 (0.840,4.663) | 0.118 | ||
| Metastatic tumor number | ||||
| 1 | Ref | |||
| 2 | 1.134 (0.487,2.642) | 0.771 | ||
| 3 | 3.353 (0.697,16.118) | 0.131 | ||
| Metastatic sites | ||||
| Single organ metastases | Ref | |||
| Multiple organs metastases | 0.563 (0.204,1.550) | 0.266 | ||
| AFP level | ||||
| >200 | Ref | |||
| <200 | 0.712 (0.323,.1.570) | 0.400 | ||
| TACE session | ||||
| 1 | Ref | |||
| ≥2 | 0.512 (0.197,1.330) | |||
| Iodine 125 seeds implantation session | ||||
| 1 | Ref | |||
| ≥2 | 0.377 (0.126,1.123) | 0.080 | ||
| Child-Pugh | ||||
| A | Ref | |||
| B | 1.315 (0.537,3.221) | 0.549 | ||
| ECOG | ||||
| 0 | Ref | Ref | ||
| 1 | 1.825 (0.644,5.166) | 0.258 | 1.282 (0.443,3.707) | 0.647 |
| 2 | 8.214 (2.152,31.345) | 0.002 | 15.365 (3.137,75.272) | 0.001 |