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. 2022 May 17;10:864191. doi: 10.3389/fcell.2022.864191

FIGURE 1.

FIGURE 1

Structure of the nuclear periphery and lamins. (A) Schematic representation of the nuclear envelope structure. The nuclear lamina lies beneath the inner nuclear membrane and interacts with nuclear proteins and chromatin at lamina-associated domains (LADs). Several nuclear lamina proteins, including lamin A/C, B1, B2, lamin B receptor (LBR), and emerin, are associated with LAD positioning. (B) Schematic structure of lamins. The lamins consist of three domains including an N-terminal head domain, a central coiled-coil rod domain, and a globular C-terminal tail domain with the NLS and Ig-fold. Lamins assemble into higher order filaments through rod domain interactions. Lamin dimers form head-to-tail polymers and then assemble into filaments in an antiparallel manner. (C) Immunofluorescence images of mouse collecting duct cells stained for lamin A/C (red) and lamin B1 (green) and DNA (blue).