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Post-translational modifications of lamins and their multifunctional roles. (A) Lamins undergo various PTMs in different domains. (B) Landscape of post-translational modifications and functions. PTMs of lamins are involved in mitosis, viral infection and immune response, nuclear shape and lamin localization, lamin interaction, gene transcription, and DNA damage repair, as well as lamin degradation (modified from Murray-Nerger et al., 2021).
