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. 2022 May 17;13:883057. doi: 10.3389/fphar.2022.883057

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Copyright © 2022 Yi, Yan, Guo, Liu, Wang, Shang, Wei, Cui, Sun, Ren and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EPO protected renal functions and morphological characteristics of DN mice. (A) The changes of body weight, (B) FBG levels, (C) serum creatinine, (D) blood urea nitrogen, (E) SOD activity, MDA, and (G) histological staining of kidney tissues in terms of HE, Masson and PAS staining. Arrows indicate the abnormal glomerular structure, arrowheads indicated the fibrosis deposition and asterisks indicate the deposition of mesangial matrix. Values are presented as mean ± SEM, for (A,B), n = 8; for (C,D), n = 3; for (E,F), n = 5. **p < 0.01 vs. Control group; ^# p < 0.05, ^## p < 0.01 vs. Model group.