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. 2022 May 17;13:883057. doi: 10.3389/fphar.2022.883057

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Copyright © 2022 Yi, Yan, Guo, Liu, Wang, Shang, Wei, Cui, Sun, Ren and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EPO activated PINK1/Parkin-mediated mitophagy in kidney tissues of DN mice. The changes of (A) LC3 mRNA expression, (B) P62 mRNA expression, (C) PINK1 mRNA expression, (D) Parkin mRNA expression, (E) the ratio of LC3B-Ⅱ/LC3B-Ⅰ, (F) P62 protein expression, (G) PINK1 protein expression, (H) Parkin protein expression, (I) Drp-1 protein expression, (J) Mfn-2 protein expression. Values are presented as mean ± SEM, n = 3. *p < 0.05, **p < 0.01 vs. Control group; ^# p < 0.05, ^## p < 0.01 vs. Model group.