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. 2022 May 31;32(7):609–620. doi: 10.1038/s41422-022-00672-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The infection frequency of SARS-CoV-2 Delta, Omicron BA.1, and Omicron BA.2 strains since January 2022 to April 2022. b Binding curves of the Omicron BA.2 spike trimer to human ACE2. K_D values were determined with Octet Data Analysis HT 12.0 software using a 1:1 global fit model. c Relative potency of WT, BA.1, and BA.2 with the ratio of their K_D values. d, e Cryo-EM density maps of the hACE2-Omicron BA.2 spike trimer complexes with hACE2 and BA.2 spike in 3:3 molar ratio (d) or in 2:3 molar ratio (e). f The locations of Omicron BA.2 mutations on the Spike trimer. Spike trimer is shown in surface. The shared mutations between BA.1 and BA.2 are colored in green and the BA.2 its own mutations are colored in red. g The locations of 16 Omicron BA.2 mutations on the RBD. RBD is shown in surface. The shared mutations between BA.1 and BA.2 are colored in green and for BA.2 its own mutations are colored in red, including S375F, T376A, D405N, R408S, and N440K.