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. 2022 May 31;32(7):609–620. doi: 10.1038/s41422-022-00672-4

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Binding of JMB2002 Fab and IgG to the Omicron BA.2 spike trimer. b Inhibition of the pseudovirus of Omicron BA.2 by JMB2002. c Cryo-EM density map of the Fab-bound Omicron BA.2 spike trimer shown as front and top views. d Top view of Fab-bound Omicron BA.2 spike trimer complex model with Fab and nanobody hidden. e Superposition of the ACE2-bound and Fab-bound Omicron BA.2 spike trimer showing that Fab binding to RBD inhibits ACE2 binding.