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. 2022 May 17;16:896880. doi: 10.3389/fnins.2022.896880

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Copyright © 2022 Sicher, Duerr, Starnes and Crowley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of major changes to the medial prefrontal cortex identified in rodent models of adolescent stress. Triangles indicate pyramidal neurons. Arrows represent the direction of the alteration, relative to non-stressed controls of the same sex. CCK, cholecystokinin; CORT, corticosterone; D2R, dopamine receptor 2; D2R GPCR illustrated in blue; DA, dopamine; E/I ratio, excitatory/inhibitory balance; IL, infralimbic cortex; mPFC, medial prefrontal cortex (indicates alterations tested throughout this region); NMDAR, N-methyl-D-aspartate receptor; PL, prelimbic cortex; PV, parvalbumin-expressing; sIPSCs, spontaneous inhibitory postsynaptic currents; sEPSCs, spontaneous excitatory postsynaptic currents; SST-28, somatostatin-28 peptide; VGAT, vesicular GABA transporter 1; VIP, vasoactive intestinal peptide.