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. 2022 May 17;13:866325. doi: 10.3389/fphar.2022.866325

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Copyright © 2022 Cui, Fu, Yang, Gao, Feng, Zhou, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of differences in prognosis, immune elements, and pathway enrichment between the two subtypes in TCGA cohort. (A–C) Kaplan–Meier survival analysis of the two clusters in TCGA (OS, overall survival; EFS, event-free survival; RFS, relapse-free survival. C1 n = 82, C2 n = 68; log-rank p-test). (D,E) Comparison of the difference in immune cell fraction and immune response between the two subtypes, with CibersortX and ssGSEA algorithm (Wilcoxon tests). (F) FLT3-ITD, NPM1, and RUNX1 mutation distribution between the two subtypes (Chi-Square tests). (G,H) Heatmaps of GSVA-based KEGG and Hallmark analysis of the two subtypes (Wilcoxon tests).