Figure 1.

Effects of ADE on the CFA-induced chronic inflammatory pain mice model. Mice were treated with distilled water (control), diclofenac sodium (positive control), ADE-M (100 mg/k), and ADE-H (600 mg/kg) daily after injection of CFA, and then mechanical allodynia (a) and thermal hyperalgesia (b) were tested among the groups. Each point represents the mean ± SEM of the paw withdrawal threshold in response to mechanical or thermal stimuli (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001 mean comparison with control group; n = 10).