Table 3.
Gender and prevalence of specific autoantibodies in ZnT8A positive (ZnT8-Ab+) and ZNT8-Ab negative (ZnT8-Ab-) in 156 type 1 diabetic (T1D) newly diagnosed children, based on the age at diagnosis (AAD).
| Children ≤ 5 | 6 ≤ children ≤ 10 | Children ≤ 10 | Children ≥ 11 | p value | |||||
|---|---|---|---|---|---|---|---|---|---|
| ZnT8-Ab+ | ZnT8-Ab- | ZnT8-Ab+ | ZnT8-Ab- | ZnT8-Ab+ | ZnT8-Ab- | ZnT8-Ab+ | ZnT8-Ab- | ZnT8-Ab+ | |
| N (%) | 25 (16.02) | 31 (19.87) | 30 (19.23) | 20 (12.82) | 55 (35.25) | 51 (32.69) | 32 (20.51) | 18 (11.53) | 0.037 |
| Sex ratio (F/M) | 1 | 1.18 | 1.09 | 1.4 | 1.04 | 1.2 | 0.56 | 0.42 | — |
| ZnT8-Ab titer (UI/ml) | 129.02 ± 55.13 | 1.00 ± 0.69 | 220.4 ± 91.29 | 1.8 ± 1.22 | 149.34 ± 73.21 | 1.27 ± 1.18 | 362.66 ± 87.73 | 0 | 0.009 |
| GADA titer (UI/ml) | 107.88 ± 54.68 | 287.2 ± 80.06 | 276.15 ± 88.11 | 349.00 ± 106.46 | 182.73 ± 72.39 | 307.8 ± 94.5 | 268.78 ± 86.68 | 419.70 ± 158.26 | NS |
| IA-2A titer (UI/ml) | 316.25 ± 166.99 | 162.97 ± 104.08 | 598.33 ± 185.42 | 334.88 ± 224.52 | 430.75 ± 176.15 | 220.28 ± 188.4 | 207.95 ± 114.59 | 201.17 ± 104.35 | NS |
T1D: type 1 diabetes; ZnT8-Ab: zinc transporter 8 autoantibodies; GADA: glutamic acid decarboxylase autoantibodies; IA-2A: antiprotein tyrosine phosphatase- (PTP-) like antigen IA-2 autoantibodies.