Table 3.
Cytokine and chemokine concentrations in cervicovaginal mucus from women with symptomatic cervical ectopy.
| Analyte | HPV-pos | HPV-neg | p valuea | ||
|---|---|---|---|---|---|
| N=35 (pg/mg) | N=28 (pg/mg) | ||||
| Median | IQR | Median | IQR | ||
| Cytokines | |||||
| IL-1β | 693.10 | (213.5-1574) | 485.50 | (313.9-1416) | 0.833 |
| IL-2 | 4.03 | (2.3-9.6) | 1.79 | (0.7-3.9) | 0.114 |
| IL-4 | 5.44 | (1.8-16.2) | 1.95 | (0.9-3.3) | 0.145 |
| IL-6 | 13.08 | (5.9-66.4) | 13.89 | (5.5-87) | 0.922 |
| IL-8 | 6435.00 | (2290-13743) | 4591.00 | (2957-8609) | 0.226 |
| IL-9 | 3.39 | (2.3-7.4) | 2.19 | (1.5-3.3) | 0.080 |
| IL-12p | 21.55 | (16.9-26.2) | 45.17 | (35.2-83.6) | 0.143 |
| IL-13 | 10.47 | (5.2-25.7) | 9.80 | (3.6-15.9) | 0.857 |
| IL-17B | 4.24 | (3.9-8.1) | 1.60 | (0.5-4.1) | 0.143 |
| IL-21 | 16.24 | (3.5-30.1) | 2.02 | (1.7-5.6) | 0.0002* |
| IL-22 | 983.60 | (463.7-2402) | 973.50 | (348.6-1710) | 0.518 |
| TNF-α | 26.20 | (13.1-44) | 17.45 | (6.8-34.9) | 0.413 |
| IFN-γ | 20.18 | (3.9-50.7) | 8.64 | (3.3-16.7) | 0.445 |
| Chemokines | |||||
| CXCL10 | 18.06 | (10.6-35.2) | 22.61 | (7.4-41.5) | 0.682 |
| CCL11 | 8.54 | (6.2-11.8) | 10.73 | (4-26.5) | 0.576 |
| CCL17 | 9.97 | (7.4-15.5) | 9.68 | (3.9-24.1) | 0.715 |
| CCL2 | 26.47 | (9.7-85.6) | 44.90 | (20.4-85.1) | 0.378 |
| CCL5 | 19.82 | (11.5-40.4) | 18.71 | (10.2-61.4) | 0.865 |
| CCL3 | 19.77 | (10.2-28.3) | 16.83 | (7.7-39.7) | 0.608 |
| CXCL9 | 22.26 | (8.7-76.9) | 11.90 | (4.2-21.1) | 0.013* |
| CXCL5 | 53.24 | (26.3-162.5) | 26.46 | (18-79.5) | 0.069 |
| CCL20 | 20.84 | (10.4-37.7) | 21.49 | (6.4-49.2) | 0.814 |
| CXCL1 | 30.06 | (18.5-77.1) | 43.35 | (12.6-75.4) | 0.926 |
| CXCL11 | 7.06 | (3.8-16.9) | 11.22 | (3.1-19.2) | 0.771 |
| CCL4 | 22.83 | (12.6-36.8) | 23.06 | (6.4-52.2) | 0.684 |
Values are given as median (IQR 25-75).
HPV, Human Papillomavirus.
HPV-pos, HPV positive samples.
HPV-neg, HPV negative samples.
a
By Mann-Whitney test.
*p < 0.05 was considered significant.