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. 2022 May 31;12:9045. doi: 10.1038/s41598-022-12032-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term polyclonal antibodies following COVID-19 recognize multiple SARS-CoV-2 epitopes, and cross-react with related human coronaviruses. Heat-maps displaying the reactivity of COVID-19 convalescent sera collected at 5 months post-diagnosis (n = 22) and naïve sera (n = 20) to individual peptides of spike, nucleoprotein, and membrane protein. For each heat-map, the left and right panels show reactivity with naïve and COVID-19 convalescent sera, respectively. The y-axis represents the linear protein sequence arranged from N-terminus (top) to C-terminus (bottom).