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. 2022 May 31;12:9045. doi: 10.1038/s41598-022-12032-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Long-lasting epitope-specific IgG antibodies to SARS-CoV-2 reveal a heterogeneous response with a small subset of shared epitopes. For each differentially reactive peptide (p-adjusted value < 0.1), the responder frequency was calculated using a cutoff defined as the mean value of the naïve sera samples plus three standard deviations (n = 20), and percent responders among the COVID-19 convalescent sera (n = 22) collected at 5 months post-diagnosis determined. Only peptides with a responder frequency greater than 10% are displayed. NCAP nucleoprotein, VEMP envelope small membrane protein, VME1 membrane protein.