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. 2022 May 31;12:9045. doi: 10.1038/s41598-022-12032-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Epitope mapping of SARS-CoV-2 spike, nucleoprotein, and membrane protein reveal distinct clusters of antibody reactivity. Differentially reactive peptides (adjusted p < 0.1, red tiles; adjusted p > 0.1, grey tiles) mapped on to their respective linear sequence. The x-axis of each panel represents the linear protein sequence arranged N-terminus (left) to C-terminus (right); y-axis represents the mean signal intensity for the COVID-19 convalescent sera (n = 22). Grey boxes demarcate epitope clusters, the sequence position is displayed for each. NCAP nucleoprotein, VME1 membrane protein, NTD N-terminal domain, RBD receptor-binding domain, RBM receptor-binding motif, FP fusion peptide, HR heptad repeat, TM transmembrane domain, CP cytoplasmic tail.