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. 2022 May 31;12:9045. doi: 10.1038/s41598-022-12032-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immunodominant SARS-CoV-2 epitopes are highly specific and discriminatory, and exhibit minimal cross-reactivity to related human coronaviruses beyond SARS-CoV. Data presented for the three immunodominant membrane protein epitopes (peptides 1–19, 145–159, and 193–207), and four spike epitopes (peptides 453–467, 557–571, 785–803, and 1253–1267). Dots represent average signal intensity (relative fluorescent units) for individual samples (open circles, naïve sera, n = 20; blue circles, COVID-19 sera, n = 22). Sequence alignments were used to identify homologous regions in related coronaviruses. P-values were calculated using the Mann–Whitney U test and adjusted for false-discovery using the Benjamini–Hochberg correction. SARS2, SARS-CoV-2; SARS, SARS-CoV; MERS, MERS-CoV; OC43, hCOV-OC43; and 229E, hCOV-229E.