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. Author manuscript; available in PMC: 2022 May 31.
Published in final edited form as: Cell Rep. 2021 Sep 21;36(12):109719. doi: 10.1016/j.celrep.2021.109719

Figure 1. Properties of the CF→PC synapse do not depend on synaptotagmin 7 in wild-type animals.

Figure 1.

(A–C) Experiments were performed in wild-type (WT) (black) and synaptotagmin 7 knockout (Syt7 KO) animals at the CF-PC synapse under conditions of low (A and B; ~0.3 mM) or high (C; ~4 mM) external calcium (Cae). (Left) Representative EPSCs with an inter-stimulus interval (ISI) of 20 ms (A and C) or evoked by a 50-Hz train (B) are shown. (Middle) The average paired-pulse ratio (PPR) is plotted as function of the ISI (A and C). The zoomed-in inset is indicated by dashed rectangles (C). The summary for the normalized average EPSC amplitudes is shown for the 50-Hz train (B). (Right) Plots with indicated mean ± SEM for the PPR at 10 ms (A and C) and the ratio EPSC10/EPSC1 (B) are shown. Statistical significance (unpaired t test; see Tables S1): not significant (n.s.). Data are shown as mean ± SEM. See also Tables S1 and S2 and Figure S1.